Publications

Nelson DC,Dave UM,Gonzalez-Juarbe N

Harnessing mRNA to unleash endolysins: A new frontier in antibacterial therapy.

Mol Ther Nucleic Acids. 2024 Sep 10;35(3):102249. doi: 10.1016/j.omtn.2024.102249. Epub 2024 Jun 26

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Chekesa B,Singh H,Gonzalez-Juarbe N,Vashee S,Wiscovitch-Russo R,Dupont CL,Girma M,Kerro O,Gumi B,Ameni G

Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.

Front Public Health. 2024;12:1399731. doi: 10.3389/fpubh.2024.1399731. Epub 2024 Aug 9

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Chekesa B,Singh H,Gonzalez-Juarbe N,Vashee S,Wiscovitch-Russo R,Dupont CL,Girma M,Kerro O,Gumi B,Ameni G

Pangenome and genomic signatures linked to the dominance of the lineage-4 of Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.

PLoS One. 2024;19(7):e0304060. doi: 10.1371/journal.pone.0304060. Epub 2024 Jul 25

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Sutherland L,Lang J,Gonzalez-Juarbe N,Pickett BE

Secondary Analysis of Human Bulk RNA-Seq Dataset Suggests Potential Mechanisms for Letrozole Resistance in Estrogen-Positive (ER+) Breast Cancer.

Curr Issues Mol Biol. 2024 Jul 6;46(7):7114-7133. doi: 10.3390/cimb46070424. Epub 2024 Jul 6

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Singh H,Gonzalez-Juarbe N,Pieper R,Yu Y,Vashee S

Predictive biomarkers for latent Mycobacterium tuberculosis infection.

Tuberculosis (Edinb). 2024 Jul;147:102399. doi: 10.1016/j.tube.2023.102399. Epub 2023 Aug 24

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McGrath ME,Xue Y,Taylor L,Dillen C,Ardanuy J,Gonzalez-Juarbe N,Baracco L,Kim R,Hart R,Assad-Garcia N,Vashee S,Frieman MB

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.

PLoS Pathog. 2024 May;20(5):e1011669. doi: 10.1371/journal.ppat.1011669. Epub 2024 May 23

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Alreja AB,Appel AE,Zhu JC,Riley SP,Gonzalez-Juarbe N,Nelson DC

SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization.

mBio. 2024 Apr 10;15(4):e0006924. doi: 10.1128/mbio.00069-24. Epub 2024 Mar 12

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Bustos IG,Wiscovitch-Russo R,Singh H,Sievers BL,Matsuoka M,Freire M,Tan GS,Cala MP,Guerrero JL,Martin-Loeches I,Gonzalez-Juarbe N,Reyes LF

Major alteration of Lung Microbiome and the Host Reaction in critically ill COVID-19 Patients with high viral load.

Res Sq. 2024 Mar 8;:. pii: rs.3.rs-3952944. doi: 10.21203/rs.3.rs-3952944/v1. Epub 2024 Mar 8

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Wiscovitch-Russo R,Ibáñez-Prada ED,Serrano-Mayorga CC,Sievers BL,Engelbride MA,Padmanabhan S,Tan GS,Vashee S,Bustos IG,Pachecho C,Mendez L,Dube PH,Singh H,Reyes LF,Gonzalez-Juarbe N

Major adverse cardiovascular events are associated with necroptosis during severe COVID-19.

Crit Care. 2023 Apr 20;27(1):155. doi: 10.1186/s13054-023-04423-8. Epub 2023 Apr 20

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Wiscovitch-Russo R,Ibáñez-Prada ED,Serrano-Mayorga CC,Sievers BL,Engelbride MA,Padmanabhan S,Tan GS,Vashee S,Bustos IG,Pachecho C,Mendez L,Dube PH,Singh H,Reyes LF,Gonzalez-Juarbe N

Necroptosis Drives Major Adverse Cardiovascular Events During Severe COVID-19.

Res Sq. 2023 Jan 21;:. pii: rs.3.rs-2468706. doi: 10.21203/rs.3.rs-2468706/v1. Epub 2023 Jan 21

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Platt MP,Lin YH,Penix T,Wiscovitch-Russo R,Vashee I,Mares CA,Rosch JW,Yu Y,Gonzalez-Juarbe N

A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial virulence fitness.

PLoS Pathog. 2022 Dec;18(12):e1011020. doi: 10.1371/journal.ppat.1011020. Epub 2022 Dec 21

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Wiscovitch-Russo R,Taal AM,Kuelbs C,Oldfield LM,Ramar M,Singh H,Fedulov AV,Gonzalez-Juarbe N

Gut and lung microbiome profiles in pregnant mice.

Front Microbiol. 2022;13:946779. doi: 10.3389/fmicb.2022.946779. Epub 2022 Dec 12

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Wiscovitch-Russo R,Singh H,Oldfield LM,Fedulov AV,Gonzalez-Juarbe N

An optimized approach for processing of frozen lung and lavage samples for microbiome studies.

PLoS One. 2022;17(4):e0265891. doi: 10.1371/journal.pone.0265891. Epub 2022 Apr 5

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Platt MP,Lin YH,Wiscovitch-Russo R,Yu Y,Gonzalez-Juarbe N

Pandemic Influenza Infection Promotes Streptococcus pneumoniae Infiltration, Necrotic Damage, and Proteomic Remodeling in the Heart.

mBio. 2022 Feb 22;13(1):e0325721. doi: 10.1128/mbio.03257-21. Epub 2022 Jan 4

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Cantwell AM,Singh H,Platt M,Yu Y,Lin YH,Ikeno Y,Hubbard G,Xiang Y,Gonzalez-Juarbe N,Dube PH

Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19.

J Virol. 2021 Sep 27;95(20):e0101021. doi: 10.1128/JVI.01010-21. Epub 2021 Jul 28

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Park SS,Gonzalez-Juarbe N,Riegler AN,Im H,Hale Y,Platt MP,Croney C,Briles DE,Orihuela CJ

Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza.

Cell Rep. 2021 Jun 15;35(11):109267. doi: 10.1016/j.celrep.2021.109267. Epub 

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Park SS,Gonzalez-Juarbe N,Martínez E,Hale JY,Lin YH,Huffines JT,Kruckow KL,Briles DE,Orihuela CJ

Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence.

mBio. 2021 May 4;12(3):. doi: 10.1128/mBio.00673-21. Epub 2021 May 4

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Lin YH,Platt MP,Gilley RP,Brown D,Dube PH,Yu Y,Gonzalez-Juarbe N

Influenza Causes MLKL-Driven Cardiac Proteome Remodeling During Convalescence.

Circ Res. 2021 Mar 5;128(5):570-584. doi: 10.1161/CIRCRESAHA.120.318511. Epub 2021 Jan 27

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Lin YH,Platt MP,Fu H,Gui Y,Wang Y,Gonzalez-Juarbe N,Zhou D,Yu Y

Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.

Mol Cell Proteomics. 2020 Dec;19(12):2030-2047. doi: 10.1074/mcp.RA120.002235. Epub 2020 Sep 22

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Beno SM,Riegler AN,Gilley RP,Brissac T,Wang Y,Kruckow KL,Jadapalli JK,Wright GM,Shenoy AT,Stoner SN,Restrepo MI,Deshane JS,Halade GV,González-Juarbe N,Orihuela CJ

Inhibition of Necroptosis to Prevent Long-term Cardiac Damage During Pneumococcal Pneumonia and Invasive Disease.

J Infect Dis. 2020 Nov 9;222(11):1882-1893. doi: 10.1093/infdis/jiaa295. Epub